Acrogeria is characterized by premature aging of the hands and feet. The main clinical feature is skin atrophy, associated with thin skin and prominent blood vessels visible across the trunk. Short stature, micrognathia, and joint hypermobility are present in many patients.
The condition can be inherited in both autosomal dominant and autosomal recessive patterns. Molecular analysis of patients with acrogeria has revealed pathogenic variants in three different genes.
Sintomi Acrogeria
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